Muscle-Bone Crosstalk in Chronic Kidney Disease: The Potential Modulatory Effects of Exercise

Chronic kidney disease (CKD) is a prevalent worldwide public burden that increasingly compromises overall health as the progresses. Two of most negatively affected tissues are bone and skeletal muscle, with CKD impacting their structure, function activity, impairing quality life these patients contributing to morbidity mortality. Whereas in this population has conventionally been associated mineral disorders, sarcopenia observed impact muscle CKD. Indeed, linked anatomically physiologically, together regulate functional metabolic mechanisms. With initial crosstalk between skeleton proposed explain formation through contraction, it now understood communication occurs interaction myokines osteokines, secretome playing pivotal role regulation activity. Regular exercise reported be beneficial health. Also, positive regulatory effect have on anatomical, functional, activity led proposal regular physical therapeutic strategy for bone-related disorders. The detection bone- muscle-derived cytokine secretion following strengthened idea cross organs. Hence, review presents an overview narrates how intrinsically communicate each other, focus potential modulation intercommunication.